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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:75253
Term: phenylarsine oxide
Definition: An arsine oxide derived from phenylarsine.
Chemical ID: MESH:C029341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDoxophenylarsine results in increased phosphorylation of RPS6KB1 proteinPMID:16183647
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]PMID:16183647
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