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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:75248
Term: potassium tellurite
Definition: A potassium salt consisting of potassium and tellurite ions in a 2:1 ratio.
Chemical ID: MESH:C026899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1affects oxidationISORGD:7321196480464CTDpotassium tellurate(IV) affects the oxidation of TXNRD1 proteinPMID:19486940
Txnrd1increases activityISORGD:7321196480464CTDpotassium tellurate(IV) results in increased activity of TXNRD1 proteinPMID:19486940
Txnrd1increases expressionISORGD:7321196480464CTDpotassium tellurate(IV) results in increased expression of TXNRD1 mRNAPMID:19486940
Txnrd1multiple interactionsISORGD:7321196480464CTDpotassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]PMID:19486940
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