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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595919
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a62
Name: cytochrome P450, family 3, subfamily a, polypeptide 62
Acc ID: CHEBI:75246
Term: rifaximin
Definition: A semisynthetic member of the class of rifamycins and non-systemic gastrointestinal site-specific broad spectrum antibiotic. Used in the treatment of traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome.
Chemical ID: MESH:C042734
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a62increases expressionISORGD:13529626480464CTDRifaximin results in increased expression of CYP3A4 mRNA

PMID:21141967 PMID:27506419
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