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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Acc ID: CHEBI:75246
Term: rifaximin
Definition: A semisynthetic member of the class of rifamycins and non-systemic gastrointestinal site-specific broad spectrum antibiotic. Used in the treatment of traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome.
Chemical ID: MESH:C042734
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1multiple interactionsISORGD:692106480464CTD[NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7A1 protein

PMID:22790967
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