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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2630
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
Acc ID: CHEBI:75172
Term: formestane
Definition: A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
Chemical ID: MESH:C014594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbmultiple interactionsEXP 6480464CTDformestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein]PMID:22120136
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