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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:7514
Term: neostigmine
Definition: A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Chemical ID: MESH:D009388
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases activityISOACHE (Homo sapiens)6480464CTDNeostigmine results in decreased activity of ACHE proteinPMID:19105816
Achedecreases activityISOAche (Mus musculus)6480464CTDNeostigmine results in decreased activity of ACHE proteinPMID:623676
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