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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases activityISOMapk1 (Rattus norvegicus)6480464CTDchrysin results in increased activity of MAPK1 proteinPMID:22864849
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDchrysin results in increased phosphorylation of MAPK1 proteinPMID:25770930
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDMAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]PMID:22864849
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 proteinPMID:25770930
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