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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityEXP 6480464CTDchrysin results in decreased activity of ABCB1 proteinPMID:27996361
Abcb1aaffects activityISOABCB1 (Homo sapiens)6480464CTDchrysin affects the activity of ABCB1 proteinPMID:15796199
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDchrysin results in decreased activity of ABCB1 proteinPMID:20457140
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDchrysin results in increased expression of ABCB1 proteinPMID:20457140
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of TopotecanPMID:20457140
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