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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects glucuronidationISORGD:13500186480464CTDUGT1A1 protein affects the glucuronidation of chrysin

PMID:10950852
increases expressionISORGD:13500186480464CTDchrysin results in increased expression of UGT1A1, chrysin results in increased expression of UGT1A1 mRNA, chrysin results in increased expression of UGT1A1 protein

PMID:10950852, PMID:11442279, PMID:15104253, PMID:16003560, PMID:17256720
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of chrysin

PMID:14557274
multiple interactionsISORGD:13500186480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA], chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter], chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin], pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA], SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA], U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]

PMID:10950852, PMID:11442279, PMID:17256720, PMID:17599282
multiple interactionsISORGD:39356480464CTDchrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]

PMID:17599282
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.