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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322701
Species: Homo sapiens
RGD Object: Gene
Symbol: MTHFD2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Acc ID: CHEBI:7507
Term: neomycin
Definition: A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections.
Chemical ID: MESH:D009355
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTHFD2decreases expressionISOMthfd2 (Mus musculus)6480464CTDNeomycin results in decreased expression of MTHFD2 mRNAPMID:30626089
MTHFD2multiple interactionsISOMthfd2 (Mus musculus)6480464CTDPlant Oils inhibits the reaction [Neomycin results in decreased expression of MTHFD2 mRNA]PMID:30626089
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