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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:7496
Term: nelfinavir
Definition: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.
Chemical ID: MESH:D019888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepdecreases expressionISOLEP (Homo sapiens)6480464CTDNelfinavir results in decreased expression of LEP proteinPMID:17668557
Lepdecreases secretionISOLep (Mus musculus)6480464CTDNelfinavir results in decreased secretion of LEP proteinPMID:19033543
Lepmultiple interactionsISOLEP (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]PMID:17668557
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