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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:7494
Term: nefazodone
Definition: A N-alkylpiperazine that has formula C25H32ClN5O2.
Chemical ID: MESH:C051752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Adecreases expressionEXP 6480464CTDnefazodone results in decreased expression of IL1A mRNAPMID:32816093
IL1Amultiple interactionsEXP 6480464CTD[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nefazodonePMID:19362101
IL1Amultiple interactionsISOIl1a (Rattus norvegicus)6480464CTD[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to nefazodonePMID:19362101
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