Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:7494
Term: nefazodone
Definition: A N-alkylpiperazine that has formula C25H32ClN5O2.
Chemical ID: MESH:C051752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:691656480464CTDnefazodone results in increased expression of DDIT3 mRNA, nefazodone results in increased expression of DDIT3 protein

PMID:24136188, PMID:27613715
multiple interactionsISORGD:691656480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluorobenzamide inhibits the reaction [nefazodone results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [nefazodone results in increased expression of DDIT3 protein]

PMID:27613715
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.