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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:74926
Term: patulin
Definition: A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.
Chemical ID: MESH:D010365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDPatulin results in increased phosphorylation of MAPK1 proteinPMID:21964610
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDPatulin results in increased phosphorylation of MAPK1 proteinPMID:34896196
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDPatulin results in increased phosphorylation of MAPK1 proteinPMID:17090621
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein]PMID:17090621
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