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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559468
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdc1
Name: mediator of DNA damage checkpoint 1
Acc ID: CHEBI:74789
Term: 9-aminoacridine
Definition: An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.
Chemical ID: MESH:D000585
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdc1multiple interactionsISORGD:13488176480464CTD[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]

PMID:26928355
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