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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346968
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A10
Name: UDP glucuronosyltransferase family 1 member A10
Acc ID: CHEBI:7476
Term: naproxen
Definition: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Chemical ID: MESH:D009288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A10increases glucuronidationEXP 6480464CTDUGT1A10 protein results in increased glucuronidation of NaproxenPMID:15535975
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