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RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:7465
Term: naltrexone
Definition: An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.
Chemical ID: MESH:D009271
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:691656480464CTDNaltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.