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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733897
Species: Homo sapiens
RGD Object: Gene
Symbol: TH
Name: tyrosine hydroxylase
Acc ID: CHEBI:7459
Term: naloxone
Definition: A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
Chemical ID: MESH:D009270
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THincreases phosphorylationISOTh (Rattus norvegicus)6480464CTDNaloxone results in increased phosphorylation of TH proteinPMID:24398105
THmultiple interactionsISOTh (Mus musculus)6480464CTD[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]PMID:25582704
THmultiple interactionsISOTh (Rattus norvegicus)6480464CTD[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH proteinPMID:24398105 PMID:25308750
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