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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2609
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf2
Name: fibroblast growth factor 2
Acc ID: CHEBI:74514
Term: 6-aminonicotinamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
Chemical ID: MESH:D015120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf2increases expressionISORGD:708236480464CTD6-Aminonicotinamide results in increased expression of FGF2 protein

PMID:12898533
Fgf2multiple interactionsISORGD:708236480464CTDIL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein]

PMID:12898533
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