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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox17
Name: SRY-box transcription factor 17
Acc ID: CHEBI:74514
Term: 6-aminonicotinamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
Chemical ID: MESH:D015120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox17decreases localizationISORGD:13133586480464CTD6-Aminonicotinamide results in decreased localization of SOX17 protein

PMID:24154490
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