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RGD ID: 70332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif3a
Name: hypoxia inducible factor 3 subunit alpha
Acc ID: CHEBI:74460
Term: 5-chloro-7-iodoquinolin-8-ol
Definition: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Chemical ID: MESH:D007464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16053516480464CTDClioquinol results in decreased expression of HIF3A mRNA

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.