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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69110
Species: Mus musculus
RGD Object: Gene
Symbol: Gata2
Name: GATA binding protein 2
Acc ID: CHEBI:74460
Term: 5-chloro-7-iodoquinolin-8-ol
Definition: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Chemical ID: MESH:D007464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata2decreases expressionISOGATA2 (Homo sapiens)6480464CTDClioquinol results in decreased expression of GATA2 proteinPMID:29966605
Gata2multiple interactionsISOGATA2 (Homo sapiens)6480464CTDGATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]PMID:29966605
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