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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:74077
Term: S-allylcysteine
Definition: An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
Chemical ID: MESH:C065299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:694736480464CTDS-allylcysteine results in decreased expression of SREBF1 protein

PMID:23465592
multiple interactionsISORGD:694736480464CTDdorsomorphin inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein], S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of and affects the localization of SREBF1 protein], S-allylcysteine inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA], sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein], STO 609 inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein]

PMID:23465592
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.