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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266
Species: Homo sapiens
RGD Object: Gene
Symbol: FAS
Name: Fas cell surface death receptor
Acc ID: CHEBI:74077
Term: S-allylcysteine
Definition: An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
Chemical ID: MESH:C065299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASmultiple interactionsEXP 6480464CTDS-allylcysteine promotes the reaction [FAS protein binds to FADD protein]; S-allylcysteine promotes the reaction [FAS protein binds to FAS protein]; S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]PMID:31067004
FASmultiple interactionsISOFas (Mus musculus)6480464CTD[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]PMID:22033380 PMID:31067004
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