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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: nuclear factor, erythroid 2 like 2
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2multiple interactionsISORGD:620360 RGD:73443215090820RGDdioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]

 
NFE2L2multiple interactionsISORGD:6203606480464CTDdioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]

PMID:28082111
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