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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734103
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H4
Name: nuclear receptor subfamily 1 group H member 4
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H4multiple interactionsISORGD:62883115090820RGDdioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]

 
NR1H4multiple interactionsISORGD:6288316480464CTDdioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]

PMID:28082111
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