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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAmultiple interactionsEXP 6480464CTDdioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]

PMID:25111127
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