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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases activityEXP 6480464CTDdioscin results in increased activity of CASP3 protein

PMID:22334414
CASP3increases expressionEXP 6480464CTDdioscin results in increased expression of CASP3 mRNA dioscin results in increased expression of CASP3 protein

PMID:29990575
CASP3multiple interactionsEXP 6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein] benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]

PMID:29990575
CASP3multiple interactionsISORGD:102896480464CTDdioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]

PMID:24146112
CASP3multiple interactionsISORGD:22756480464CTDdioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]

PMID:24146112
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