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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6multiple interactionsISOIl6 (Rattus norvegicus) or Il6 (Mus musculus)15090820RGDdioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver] 
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDdioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]PMID:24146112
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDdioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]PMID:24146112 PMID:28082111
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