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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a2
Name: solute carrier family 2 member 2
Acc ID: CHEBI:73918
Term: 3-O-methyl-D-glucose
Definition: A D-aldohexose that is D-glucose in which the hydrogen of the hydroxy group at position 3 has been substituted by a methyl group. It is a non-metabolisable glucose analogue that is not phosphorylated by hexokinase and is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.
Chemical ID: MESH:D019325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a2increases uptakeEXP 6480464CTDSLC2A2 protein results in increased uptake of 3-O-MethylglucosePMID:10825458
Slc2a2multiple interactionsEXP 6480464CTDCytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]PMID:10825458
Slc2a2increases uptakeISORGD:113066480464CTDSLC2A2 protein results in increased uptake of 3-O-MethylglucosePMID:15986457
Slc2a2multiple interactionsISORGD:113066480464CTDFluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]PMID:15986457
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