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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:25036480464CTD1, 2-Dimethylhydrazine results in decreased activity of NQO1 protein

PMID:19497424, PMID:29108773
multiple interactionsISORGD:25036480464CTDasiatic acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased activity of NQO1 protein], hesperetin inhibits the reaction [1, 2-Dimethylhydrazine results in decreased activity of NQO1 protein]

PMID:19497424, PMID:29108773
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.