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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733705
Species: Homo sapiens
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1decreases expressionISOCtnnb1 (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of CTNNB1 mRNAPMID:22206623
CTNNB1decreases expressionISOCtnnb1 (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of CTNNB1 mRNAPMID:32387197
CTNNB1increases expressionISOCtnnb1 (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in increased expression of CTNNB1 proteinPMID:29031619 PMID:29999212
CTNNB1increases mutagenesisISOCtnnb1 (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 genePMID:12628520
CTNNB1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CTNNB1 mRNAPMID:22206623
CTNNB1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTD[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; Artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]; chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]; epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]PMID:12628520 PMID:29031619 PMID:29999212
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