GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CAT | decreases activity | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | 1,2-Dimethylhydrazine results in decreased activity of CAT protein | PMID:16338953 PMID:16733082 PMID:19497424 PMID:19523937 PMID:31925992 PMID:32387197 PMID:34627785 | CAT | decreases activity | ISO | Cat (Mus musculus) | 6480464 | CTD | 1,2-Dimethylhydrazine results in decreased activity of CAT protein | PMID:30090573 | CAT | decreases expression | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | 1,2-Dimethylhydrazine results in decreased expression of CAT; 1,2-Dimethylhydrazine results in decreased expression of CAT mRNA | PMID:22326950 PMID:32387197 | CAT | decreases expression | ISO | Cat (Mus musculus) | 6480464 | CTD | 1,2-Dimethylhydrazine results in decreased expression of CAT mRNA | PMID:22206623 | CAT | multiple interactions | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | 4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CAT]; Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein] | PMID:16338953 PMID:19497424 PMID:19523937 PMID:22326950 PMID:31925992 PMID:34627785 | CAT | multiple interactions | ISO | Cat (Mus musculus) | 6480464 | CTD | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CAT mRNA; Arsenic Trioxide affects the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein] | PMID:22206623 PMID:30090573 | |
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