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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTD1,2-Dimethylhydrazine results in decreased activity of CAT proteinPMID:16338953 PMID:16733082 PMID:19497424 PMID:19523937 PMID:31925992 PMID:32387197 PMID:34627785
Catdecreases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in decreased expression of CAT; 1,2-Dimethylhydrazine results in decreased expression of CAT mRNAPMID:22326950 PMID:32387197
Catmultiple interactionsEXP 6480464CTD4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CAT]; Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]PMID:16338953 PMID:19497424 PMID:19523937 PMID:22326950 PMID:31925992 PMID:34627785
Catdecreases activityISOCat (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in decreased activity of CAT proteinPMID:30090573
Catdecreases expressionISOCat (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of CAT mRNAPMID:22206623
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CAT mRNA; Arsenic Trioxide affects the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]PMID:22206623 PMID:30090573
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