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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plin2
Name: perilipin 2
Acc ID: CHEBI:73726
Term: GW 501516
Definition: An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.
Chemical ID: MESH:C425931
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plin2increases expressionISOPLIN2 (Homo sapiens)6480464CTDGW 501516 results in increased expression of PLIN2 mRNAPMID:23737761
Plin2multiple interactionsISOPLIN2 (Homo sapiens)6480464CTD[GW 501516 binds to PPARD protein] which results in increased expression of PLIN2 mRNA; PPARD mutant form inhibits the reaction [GW 501516 results in increased expression of PLIN2 mRNA]PMID:16197558 PMID:23737761
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