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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:73468
Term: masoprocol
Definition: The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.
Chemical ID: MESH:D009637
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDMasoprocol results in increased expression of HMOX1 mRNA, Masoprocol results in increased expression of HMOX1 protein

PMID:18852027
increases expressionISORGD:107176480464CTDMasoprocol results in increased expression of HMOX1 protein

PMID:23942037
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.