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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:73390
Term: promegestone
Definition: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Chemical ID: MESH:D011397
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1increases expressionISORGD:7320356480464CTDPromegestone results in increased expression of SP1 mRNA Promegestone results in increased expression of SP1 protein

PMID:16807381
Sp1multiple interactionsISORGD:7320356480464CTDmithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]] Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]

PMID:16807381
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