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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331975
Species: Mus musculus
RGD Object: Gene
Symbol: Pomc
Name: pro-opiomelanocortin-alpha
Acc ID: CHEBI:73364
Term: 8-OH-DPAT
Definition: A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Chemical ID: MESH:D017371
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcmultiple interactionsISOPomc (Rattus norvegicus)6480464CTD[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]PMID:22265196
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