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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733595
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB2
Name: adrenoceptor beta 2
Acc ID: CHEBI:73288
Term: CGP 12177
Definition: A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Chemical ID: MESH:C033394
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADRB2affects bindingEXP 6480464CTDCGP 12177 binds to ADRB2 proteinPMID:12535855 PMID:21870877
ADRB2multiple interactionsEXP 6480464CTD[CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; CGP 12177 binds to and results in decreased activity of ADRB2 protein; CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB2 protein]; N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB2 protein]PMID:12535855 PMID:14730417 PMID:21870877
ADRB2affects bindingISOAdrb2 (Rattus norvegicus)6480464CTDCGP 12177 binds to ADRB2 proteinPMID:17628611 PMID:2462161 PMID:9593075
ADRB2multiple interactionsISOAdrb2 (Rattus norvegicus)6480464CTDAtenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]PMID:2462161
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