GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ADRB2 | affects binding | EXP | | 6480464 | CTD | CGP 12177 binds to ADRB2 protein | PMID:12535855 PMID:21870877 | ADRB2 | multiple interactions | EXP | | 6480464 | CTD | [CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; CGP 12177 binds to and results in decreased activity of ADRB2 protein; CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB2 protein]; N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB2 protein] | PMID:12535855 PMID:14730417 PMID:21870877 | ADRB2 | affects binding | ISO | Adrb2 (Rattus norvegicus) | 6480464 | CTD | CGP 12177 binds to ADRB2 protein | PMID:17628611 PMID:2462161 PMID:9593075 | ADRB2 | multiple interactions | ISO | Adrb2 (Rattus norvegicus) | 6480464 | CTD | Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein] | PMID:2462161 | |
Go Back to source page | Continue to Ontology report |