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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731289
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB1
Name: adrenoceptor beta 1
Acc ID: CHEBI:73288
Term: CGP 12177
Definition: A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Chemical ID: MESH:C033394
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDCGP 12177 binds to ADRB1 protein

PMID:12535855, PMID:15060759, PMID:21870877
increases activityEXP 6480464CTDCGP 12177 results in increased activity of ADRB1 protein

PMID:12761341
multiple interactionsEXP 6480464CTD[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP, [CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP, [CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP, Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein], Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein], CGP 12177 binds to and results in decreased activity of ADRB1 protein, CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB1 protein], CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein], CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP], CGP 20712A inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein], Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], N-(3-hydroxy-1-(naphthalen-1-yl)-1, 8, 11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4, 4-difluoro-4, 4a-dihydro-5-(thiophen-2-yl)-4-bora-3a, 4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB1 protein], Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Propranolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein], Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP], Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

PMID:12535855, PMID:12761341, PMID:14730417, PMID:15060759, PMID:21870877
affects bindingISORGD:20596480464CTDCGP 12177 binds to ADRB1 protein

PMID:10217540, PMID:17628611, PMID:2462161, PMID:9593075
multiple interactionsISORGD:20596480464CTDAtenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein], CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein], Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein], nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein], Propranolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]

PMID:2462161
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.