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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:73224
Term: allyl isothiocyanate
Definition: An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Chemical ID: MESH:C004471
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3multiple interactionsISORGD:13441636480464CTDallyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-4-chlorophenylimidazo2 1-b1 3thiazole-5-carbaldehyde O-3 4-dichlorobenzyloxime results in increased expression of CYP2B6 mRNA]] allyl isothiocyanate inhibits the reaction [NR1I3 protein promotes the reaction [6-4-chlorophenylimidazo2 1-b1 3thiazole-5-carbaldehyde O-3 4-dichlorobenzyloxime results in increased expression of CYP3A4 mRNA]]

PMID:25069801
Nr1i3multiple interactionsISORGD:15526296480464CTDallyl isothiocyanate inhibits the reaction [[1 4-bis2-3 5-dichloropyridyloxybenzene co-treated with NR1I3 protein] results in increased expression of CYP2B10 mRNA]

PMID:25069801
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