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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:73224
Term: allyl isothiocyanate
Definition: An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
Chemical ID: MESH:C004471
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases activityISORGD:106526480464CTDallyl isothiocyanate results in increased activity of GCLC protein

PMID:24036144
Gclcincreases expressionISORGD:106526480464CTDallyl isothiocyanate results in increased expression of GCLC mRNA

PMID:24036144
Gclcmultiple interactionsISORGD:106526480464CTDNFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA]

PMID:24036144
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