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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552629
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:73172
Term: acifluorfen
Definition: A member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.
Chemical ID: MESH:C018425
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3decreases response to substanceEXP 6480464CTDNR1I3 gene mutant form results in decreased susceptibility to acifluorfenPMID:26928356
Nr1i3multiple interactionsEXP 6480464CTDNR1I3 gene mutant form inhibits the reaction [acifluorfen results in increased expression of CYP2B10 mRNA]PMID:26928356
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