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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:73167
Term: concanamycin A
Definition: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
Chemical ID: MESH:C036978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases expressionISORGD:7309356480464CTDconcanamycin A results in increased expression of HIF1A protein

PMID:25981168
Hif1amultiple interactionsISORGD:7309356480464CTDlapatinib inhibits the reaction [concanamycin A results in increased expression of HIF1A protein]

PMID:25981168
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.