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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:73158
Term: sirtinol
Definition: A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine.
Chemical ID: MESH:C439060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAincreases localizationEXP 6480464CTDsirtinol results in increased localization of RELA proteinPMID:21745208
RELAmultiple interactionsEXP 6480464CTDsirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]PMID:23257246
RELAmultiple interactionsISORela (Mus musculus)6480464CTDsirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]PMID:22717288
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