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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: RT1-Db1
Name: RT1 class II, locus Db1
Acc ID: CHEBI:73044
Term: lumiracoxib
Definition: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Chemical ID: MESH:C473384
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RT1-Db1affects response to substanceISOHLA-DRB1 (Homo sapiens)6480464CTDHLA-DRB1 gene SNP affects the susceptibility to lumiracoxibPMID:20639878
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