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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:72583
Term: WR-1065
Definition: An alkanethiol that is the N-3-aminopropyl derivative of cysteamine. Used as the S-phosphorylated prodrug, amifostine, for cytoprotection in cancer chemotherapy and radiotherapy.
Chemical ID: MESH:C020174
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases activityISORGD:113306480464CTDWR 1065 results in increased activity of SOD2

PMID:21945096
Sod2increases expressionISORGD:7308726480464CTDWR 1065 results in increased expression of SOD2 mRNA WR 1065 results in increased expression of SOD2 protein

PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396
Sod2multiple interactionsISORGD:113306480464CTD[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2] TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]

PMID:21945096
Sod2multiple interactionsISORGD:7308726480464CTDhelenalin inhibits the reaction [WR 1065 results in increased expression of SOD2 protein] WR 1065 results in increased expression of and results in increased activity of SOD2 protein

PMID:16540396 PMID:17388698
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