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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734300
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2l11
Name: BCL2 like 11
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11increases expressionISOBCL2L11 (Homo sapiens)6480464CTDtemozolomide results in increased expression of BCL2L11 mRNA; temozolomide results in increased expression of BCL2L11 proteinPMID:26418950
Bcl2l11multiple interactionsISOBCL2L11 (Homo sapiens)6480464CTDBCL2L11 mutant form inhibits the reaction [temozolomide results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [temozolomide results in increased expression of BCL2L11 mRNA]PMID:26418950
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