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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733730
Species: Mus musculus
RGD Object: Gene
Symbol: Mlh1
Name: mutL homolog 1
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlh1affects response to substanceEXP 6480464CTDMLH1 protein affects the susceptibility to temozolomidePMID:12967659
Mlh1affects response to substanceISOMLH1 (Homo sapiens)6480464CTDMLH1 protein affects the susceptibility to temozolomidePMID:18430789
Mlh1multiple interactionsISOMLH1 (Homo sapiens)6480464CTD[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MLH1 proteinPMID:20980775
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