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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61989
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ankrd1
Name: ankyrin repeat domain 1
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ankrd1affects response to substanceISOANKRD1 (Homo sapiens)6480464CTDANKRD1 mRNA affects the susceptibility to temozolomidePMID:16365179
Ankrd1increases expressionISOANKRD1 (Homo sapiens)6480464CTDTemozolomide results in increased expression of ANKRD1 mRNAPMID:31758290
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